Earth-to-Air Versus Air-to-Air Heat Exchangers: A Numerical Study on the Energetic,Economic, and Environmental Performances for Italian Office Buildings

Abstract

Earth-to-air (EAHX) and/or air-to-air (AAHX) heat exchangers can be conveniently inserted in heating, ventilation, and air conditioning (HVAC) systems to obtain relevant energy saving. In this article, the subject is analyzed for an office building located in two Italian localities: Milan (Northern Italy, with cold winters and hot summers) and Palermo (Southern Italy, with mild winters and very hot summers). A dynamic building energy performance simulation software is used to simulate a designed office building. The HVAC system is based on fan-coils and primary air, with or without EAHX and AAHX. The seasonal analysis shows better energy results for AAHX in winter and EAHX in summer, respectively. The yearly analysis shows that the EAHX is preferable in hot or mild climates. Successively, the EAHX and AAHX are combined: based on the previous seasonal results, the first one is activated in summer, while the second in winter. The combination of the two technologies is preferable for Milan (energy saving up to about 75%) compared to Palermo (saving up to about 60%). Finally, the analyses of the equivalent CO₂ emissions and discounted payback are reported.     

Long-Term Effects of Ionizing Radiation on the Hippocampus: Linking Effects of the Sonic Hedgehog Pathway Activation with Radiation Response

Radiation therapy represents one of the primary treatment modalities for primary and metastatic brain tumors. Although recent advances in radiation techniques, that allow the delivery of higher radiation doses to the target volume, reduce the toxicity to normal tissues, long-term neurocognitive decline is still a detrimental factor significantly affecting quality of life, particularly in pediatric patients. This imposes the need for the development of prevention strategies. Based on recent evidence, showing that manipulation of the Shh pathway carries therapeutic potential for brain repair and functional recovery after injury, here we evaluate how radiation-induced hippocampal alterations are modulated by the constitutive activation of the Shh signaling pathway in Patched 1 heterozygous mice (Ptch1^+/−). Our results show, for the first time, an overall protective effect of constitutive Shh pathway activation on hippocampal radiation injury. This activation, through modulation of the proneural gene network, leads to a long-term reduction of hippocampal deficits in the stem cell and new neuron compartments and to the mitigation of radio-induced astrogliosis, despite some behavioral alterations still being detected in Ptch1^+/− mice. A better understanding of the pathogenic mechanisms responsible for the neural decline following irradiation is essential for identifying prevention measures to contain the harmful consequences of irradiation. Our data have important translational implications as they suggest a role for Shh pathway manipulation to provide the therapeutic possibility of improving brain repair and functional recovery after radio-induced injury.     

A Photochemical Route to Benzo[a]carbazoles via Domino Elimination/Electrocyclization of 2‐Aryl‐3‐(1‐tosylalkyl)indoles

The photochemical synthesis of benzo[a]carbazoles from easily synthesizable 2‐aryl‐3‐(1‐tosylalkyl)indoles is presented. Irradiation of these substrates in polar aprotic solvents (acetone or THF) gives selectively the target products in satisfactory yields. This versatile and efficient procedure promises to be a useful alternative to the multistep strategies reported in the literature.     

Numerical Investigation of the Heating Process of the Walls in Steam Sterilizers

The basic principle of steam sterilization is based on high heat transfer rates from the steam to the medical device. In order to carry out this process as well as possible, the walls of the pressure chamber must be preheated. One way is to heat it with steam from the inside. To investigate this process, a three-phase CFD model was developed, which can be used to determine the saturation temperature as a function of the partial pressure using a user-defined function. For validation, the pressure, temperature (fluid and solid) and condensate content were measured. Results show that the model is excellently suited for predicting all relevant variables.     

Occurrence and survival of Campylobacter spp. in dairy matrices investigated by viability qPCR

The aim of this study was to investigate the survival of Campylobacter jejuni in dairy matrices by viability qPCR. Survival in UHT milk was examined first and the cheese outbreak strain, C. jejuni 11 218 showed enhanced tendency to become viable but nonculturable (VBNC). It survived for long at different pH values, in raw and fermented milk and cheese. Viability qPCR was also used to examine the occurrence of viable Campylobacter spp. in raw milk, detecting the bacteria in 40.9% of 25 mL samples negative on culture. Results showed that viability qPCR is valuable in estimating Campylobacter risk in dairy products.     

On the Role of Temperature in the Depolymerization of PET by FAST-PETase: An Atomistic Point of View on Possible Active Site Pre-Organization and Substrate-Destabilization Effects

Enzyme FAST-PETase, recently obtained by a machine learning approach, can depolymerize poly(ethylene terephthalate) (PET), a synthetic resin employed in plastics and in clothing fibers. Therefore it represents a promising solution for the recycling of PET-based materials. In this study, a model of PET was adopted to describe the substrate, and all-atoms classical molecular dynamics (MD) simulations on apo- and substrate-bound FAST-PETase were carried out at 30 and 50 °C to provide atomistic details on the binding step of the catalytic cycle. Comparative analysis shed light on the interactions occurring between the FAST-PETase and 4PET at 50 °C, the optimal working conditions of the enzyme. Pre-organization of the enzyme active and binding sites has been highlighted, while MD simulations of FAST-PETase:4PET pointed out the occurrence of solvent-inaccessible conformations of the substrate promoted by the enzyme. Indeed, neither of these conformations was observed during MD simulations of the substrate alone in solution performed at 30, 50 and 150 °C. The analysis led us to propose that, at 50 °C, the FAST-PETase is pre-organized to bind the PET and that the interactions occurring in the binding site can promote a more reactive conformation of PET substrate, thus enhancing the catalytic activity of the enzyme.     

Synthesis of 3‐(2‐Nitroalkyl)pyrroles from Sulfonylpyrroles and their Conversion to 6‐Azaindole Derivatives

The reaction of sulfonylpyrroles with nitroalkanes in the presence of KF/alumina generates 3‐(2‐nitroalkyl)pyrroles in good yields. These compounds can be converted into trisubstituted 6‐azaindoles by a sequence of reactions comprising reduction of the nitro group, Pictet–Spengler cyclization and final oxidative aromatization.